The rise of ubiquitous computing and pervasive technology like Mixed Reality (MR) and the Internet of Things (IoT) causes the user interface starts to shift from the touch screens to the surrounding environment. However, the inclusive design has not adequately introduced the accessibility of these emerging technologies to people with physical disability. In this context, a new approach for these people seems necessary in relation to interface design for the sake of accessibility. Unlike traditional inclusive design where an object or device need to embrace different types of users, here we question whether users can adapt to one flexible and customizable system. In this paper, we present an “inclusive” Natural User Interface (NUI), which enables people with physical disabilities to interact with the spatial computing environment.