This chapter explores the integration of strategic design within the contexts of industry and business, emphasising its transformative potential across economic, technological, and human aspects complementing the public perspective on strategic design as discussed in Chapter 2. Beginning with historical perspectives on strategy and design's evolving roles through industrialization, it delves into the impacts of technological revolutions and design's pivot towards addressing complex organisational challenges. Highlighting key concepts like design thinking, the fusion of design and management, and the significance of technological innovation, it underscores strategic design's role in fostering innovation, sustainability, and competitive advantage from the perspective of organisation design. Case studies illustrate the application of strategic design principles, offering insights into its practical implications for organisational transformation reflecting on Galbraith’s Star Model™ (2002) and the relationship between strategy, structure, processes, rewards and people. The Star Model™ as a framework supporting the implementation of a strategy is a well known approach in organisation design and in the corporate world (Galbraith, 2017). The presented cases shed light on various aspects of the model and are examples for a multidisciplinary approach that reveals strategic design as a critical tool for navigating contemporary challenges, advocating for a holistic, user centred methodology that bridges creativity, strategy, technology and the human in the organisational system. Starting with a case, in which a large-scale transformation project is taking place in a high-tech organisation, the documentation and guidance of complex work routines from paper to digital is changing – the aspect of processing information is the starting point where the design agent is acting. The second case deals with the development of an application for employees who can choose green pension funds based on their values within a reward program – Service Designers developed a concept for a 7-step process that enables this offer. The third case is a preparation of employees in a large international corporation which are going to face a major transformation in the near future – the design intervention here is a systemic approach in coaching the employees to reflect their perspectives and gain flexibility therein. The final case is looking into setting strategic goals for testing sustainable living solutions with advanced monitoring systems – the approach blends design and strategy for user-centred innovation and emphasises user involvement, systems thinking, and sustainability.