This paper introduces the concept of ‘Transformational Practises’ as a prospective design-led integrative space to conduct multidisciplinary research aiming at exceptionally innovative and/or unconventional research aiming for a high trans-formational impact. Based on a range of selected examples, the authors underpin the fundamental principles of this new framework to propose a criteria to assess prospective and multidisciplinary design-led transformations. In the process, it places design as a distinctive and fundamental activity to develop transforma-tional impact in research that aligns the applied arts (arts and design), with the prospective sciences (e.g., AI and synthetic biology), and prospective sociology (e.g., economics and policy). Finally, it combines the concepts of structured adversarial collaborations, knowledge vectors, and transformational practises metrics to integrate this area into established models of academic assessment.