This research project proposes the formation of “Localised Design Practice” as a new framework for working between Thai designers and Thai hand weavers. The overarching principle is that the disciplinary knowledge of design is localised and evolves according to what has been learnt from the local knowledge. This framework is directed to form long-lasting and mutually beneficial development projects for the designers and the weavers. The research project has emerged from a concern with the politics of knowledge in that the disciplinary knowledge of design is considerably more dominant than the local knowledge of hand weaving in current textiles design development projects in Thailand. This state of affairs poses the risk that local knowledge is suppressed and diminished by the act of design development. This research project was realised through a hybrid methodology utilizing theoretical frameworks of critical ethnography and grounded theory with apprenticeship and making practices. The research activities were divided into two parts. The first part explored apprenticeship and learning Thai hand weaving within its contexts in Thailand. The second part aimed at the integration of the two forms of knowledge, research being conducted both in the UK and Thailand. The research has identified that, although Thai hand weaving and design are fundamentally different, they share many qualities, hence knowledge integration is actually possible. Further research could test this framework to make changes in real settings, and to study the applicability of this framework in other contexts.