This article investigates the development and application of key performance indicators for global product development. Two in-depth, longitudinal case studies with multinational Danish manufacturing companies were conducted, and highlight how key performance indicators, typically used for collocated, cross-functional product development, do not provide the predictive insight required to avoid the additional risks encountered in the global product development environment. Grounded in the case study results and building on established methodologies in performance measurement literature, a framework was developed and validated in two additional Danish companies to support project managers to develop: preventive indicators, which support the avoidance of identified risks, and outcome indicators, which support the measurement towards the attainment of project objectives. The study is unique as it is one of the very few longitudinal studies of engineering design activities in a global context, providing the in-depth contextual understanding towards key risks and their influence on performance; an important step to support researchers and practitioners with the development of preventive measures.