We imagine the built environment of the future as a ‘bio-hybrid machine for living in’ that will sense and react to activities within the space in order to provide experiences and services that will elevate quality of life while coexisting seamlessly with humans and the natural environment. The study of Hierarchical design in biological materials has the potential to alter the way designers/ engineers/ craftsmen of the future engage with materials in order to realise such visions. We are exploring this design approach using digital manufacturing technologies such as jacquard weaving and 3D printing.